Leishmania amazonensis infection impairs dendritic cell 1 migration from the inflammatory site to the draining lymph 2 node 3 4
نویسندگان
چکیده
4 Micely D. R. Hermida, Priscila G. Doria, Angela M. P. Taguchi, José O. Mengel, 5 Washington LC dos-Santos 6 7 Centro de Pesquisas Gonçalo Moniz, Oswaldo Cruz Foundation, Fiocruz, LPBI, 8 Salvador, Brazil. 9 2 Instituto Oswaldo Cruz, Oswaldo Cruz Foundation, Fiocruz, Rio de Janeiro, Brazil and 10 Faculty of Medicine of Petrópolis, FMP-FASE, Petrópolis, Brazil 11 12 Corresponding author: [email protected] 13 14 Email addresses: 15 MDRH: [email protected] 16 PGD: [email protected] 17 AMPT: [email protected] 18 JOM: [email protected] 19 WLCS: [email protected] 20
منابع مشابه
Leishmania amazonensis infection impairs dendritic cell migration from the inflammatory site to the draining lymph node
BACKGROUND In vitro studies show that Leishmania infection decreases the adhesion of inflammatory phagocytes to connective tissue by a mechanism dependent on the modulation of integrin function. However, we know little about the influence of this reduction in leukocyte adhesion on parasite dissemination from the infection site. METHODS In this work, we used a model of chronic peritonitis indu...
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Differently from others Leishmania species, infection by the protozoan parasite L. amazonensis is associated with a lack of antigen-specific T-cell responses. Dendritic cells (DC) are essential for the innate immune response and for directing the differentiation of T-helper lymphocytes. Previously, we showed that L. amazonensis infection impairs DC activation through the activation of adenosine...
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Initiation of productive immune responses against Leishmania depends on the successful transition of dendritic cells (DC) from an immature to a mature phenotype. This process is characterized by high CD40 surface expression as well as interleukin-12 production, which are frequently seen in response to L. major infection. In vivo footpad infection of C3HeB/FeJ mice for 7 days with L. amazonensis...
متن کاملBlocking Junctional Adhesion Molecule C Enhances Dendritic Cell Migration and Boosts the Immune Responses against Leishmania major
The recruitment of dendritic cells to sites of infections and their migration to lymph nodes is fundamental for antigen processing and presentation to T cells. In the present study, we showed that antibody blockade of junctional adhesion molecule C (JAM-C) on endothelial cells removed JAM-C away from junctions and increased vascular permeability after L. major infection. This has multiple conse...
متن کاملImpaired expression of inflammatory cytokines and chemokines at early stages of infection with Leishmania amazonensis.
Infection of mice with Leishmania major results in disease progression or resolution, largely depending on the genetic backgrounds of the mouse strains. Infection with Leishmania amazonensis, on the other hand, causes progressive cutaneous lesions in most inbred strains of mice. We hypothesized that deficient activation of early immune responses contributes to the pathogenesis in L. amazonensis...
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تاریخ انتشار 2014